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TCS ERK 11e, Tocris Bioscience™

Catalog No. 446510 Shop All R&D Systems Products
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective ERK2 inhibitor

Potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable.

Chemical Identifiers

CAS 896720-20-0
Molecular Formula C24H20Cl2FN5O2
Molecular Weight (g/mol) 500.355
InChI Key WUTVMXLIGHTZJC-OAQYLSRUSA-N
Synonym vx-11e, vtx-11e, vx 11e, 4-2-2-chloro-4-fluorophenyl amino-5-methylpyrimidin-4-yl-n-1s-1-3-chlorophenyl-2-hydroxyethyl-1h-pyrrole-2-carboxamide, vertex-11e, pyrimidylpyrrole, 11e, tcs erk 11e, vx-11e tcs erk 11e, 4-2-2-chloro-4-fluoroanilino-5-methylpyrimidin-4-yl-n-1s-1-3-chlorophenyl-2-hydroxyethyl-1h-pyrrole-2-carboxamide, 4-2-2-chloro-4-fluorophenyl amin-o-5-methyl-4-pyrimidinyl-n-1s-1-3-chlorophen-yl-2-hydroxyethyl-1h-pyrrole-2-carboxamide
PubChem CID 11634725
IUPAC Name 4-[2-(2-chloro-4-fluoroanilino)-5-methylpyrimidin-4-yl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide
SMILES CC1=CN=C(N=C1C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl

Specifications

Quantity 10 mg
Formula Weight 500.35
Percent Purity >98%
Chemical Name or Material TCS ERK 11e

Safety and Handling

Recommended Storage Store at -20°C
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