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Enzo Life Sciences Temozolomide (100mg). CAS: 85622-93-1

Antitumor and antiangiogenic compound. DNA alkylating agent. Induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA. Inactivates DNA repair protein O(6)-alkylguanine DNA alkyltransferase (AGT) in base excision repair (BER) pathway. Chemotherapeutic agent. Modifies drug resistance. Alternative name: 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO; slightly soluble in water. Long Term Storage: -20°C.
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