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Terfenadine, Tocris Bioscience™

Catalog No. 394850 Shop All R&D Systems Products
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H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker

Histamine H1 receptor antagonist. Also blocks KV11.1 (hERG) and Kir6 (KATP) channels (IC50 values are 204 nM and 1.2 μM respectively). Inhibits the delayed rectifier K+ current (IKr) in guinea pig ventricular myocytes (IC50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo.

Chemical Identifiers

CAS

50679-08-8

Molecular Formula

C32H41NO2

Molecular Weight (g/mol)

471.69

MDL Number

MFCD00079622

InChI Key

GUGOEEXESWIERI-UHFFFAOYNA-N

Synonym

terfenadine, seldane, ternadin, triludan, teldane, allerplus, teldanex, aldaban, terdin, terfenadina

PubChem CID

5405

ChEBI

CHEBI:9453

IUPAC Name

1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol

SMILES

CC(C)(C)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1

Specifications

Quantity

50 mg

Formula Weight

471.67

Percent Purity

>98%

Chemical Name or Material

Terfenadine

Recommended Storage

Store at +4°C
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