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TG 003, Tocris Bioscience™

Catalog No. p-4816716 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B

Potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo.

Chemical Identifiers

CAS 719277-26-6
Molecular Formula C13H15NO2S
Molecular Weight (g/mol) 249.328
InChI Key BGVLELSCIHASRV-QPEQYQDCSA-N
Synonym clk inhibitor, clk inhibitor, tg003, z-1-3-ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene propan-2-one, 1z-1-3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene propan-2-one, cdc2-like kinase inhibitor, tg003, z-1-3-ethyl-5-methoxybenzo d thiazol-2 3h-ylidene propan-2-one, cdc2-like kinase inhibitor, 1-2z-3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene propan-2-one, d06mbi, 1-3-ethyl-5-methoxy-2 3h-benzothiazolylidene-2-propanone
PubChem CID 1893668
IUPAC Name (1Z)-1-(3-ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one
SMILES CCN1C2=C(C=CC(=C2)OC)SC1=CC(=O)C

Specifications

Quantity 10 mg
Formula Weight 249.33
Percent Purity >98%
Chemical Name or Material TG 003

Safety and Handling

Recommended Storage Store at +4°C
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