Thapsigargin, 95%, Thermo Scientific Chemicals

Thapsigargin- induces down regulation of the EGF receptor is independent of protein kinase C activation. It is also used as an inducer of stored Ca2+ release.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Thapsigargin- induces down regulation of the EGF receptor is independent of protein kinase C activation. It is also used as an inducer of stored Ca2+ release.

Solubility
Soluble in DMSO (20 mg/ml), ethanol (20 mg/ml), and acetone.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C.

Chemical Identifiers

CAS

67526-95-8

Molecular Formula

C34H50O12

Molecular Weight (g/mol)

650.76

MDL Number

MFCD00083511

InChI Key

IXFPJGBNCFXKPI-FSIHEZPISA-N

PubChem CID

126969181

SMILES

CCCCCCCC(=O)O[C@@H]1[C@@H](OC(=O)C(\C)=C/C)C(C)=C2[C@@H]3OC(=O)[C@@](C)(O)[C@@]3(O)[C@H](C[C@](C)(OC(C)=O)[C@@H]12)OC(=O)CCC

Color

White

Quantity

1 mg

Sensitivity

Light sensitive

Merck Index

14,9272

Synonym

thapsigargin, unii-z96bq26rzd, z96bq26rzd, chembl96926, octanoic acid 3s-3alpha, 3abeta, 4alpha, 6beta, 6abeta, 7beta, 8alpha z , 9balpha-6-acetyloxy-2,3,-3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-2-methyl-1-oxo-2-butenyl oxy-2-oxo-4-1-oxobutoxy-azuleno 4,5-b furan-7-yl ester, octanoic acid, 6-acetyloxy-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-2-methyl-1-oxo-2-butenyl oxy-2-oxo-4-1-oxobutoxy azuleno 4,5-b furan-7-yl ester, 3s-3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha z ,9balpha, tg1, --thapsigargin, octanoic acid 3s-3alpha, 3abeta, 4alpha, 6beta,6abeta, 7beta, 8alpha z , 9balpha-6-acetyloxy-2,3,-3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-2-methyl-1-oxo-2-butenyl oxy-2-oxo-4-1-oxobutoxy-azuleno 4,5-b furan-7-yl ester, octanoic acid 3s-3alpha, 3abeta, 4alpha,6beta, 6abeta, 7beta, 8alpha z , 9balpha-6-acetyloxy-2,3,-3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-2-methyl-1-oxo-2-butenyl oxy-2-oxo-4-1-oxobutoxy-azuleno 4,5-b furan-7-yl ester

Solubility Information

Soluble in DMSO (20mg/ml),ethanol (20mg/ml),and acetone.

IUPAC Name

[(3S,3aR,4S,6S,6aS,7S,8S,9bR)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-(2-methylbut-2-enoyloxy)-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate

Formula Weight

650.75

Percent Purity

95%

Physical Form

Solid Film

Chemical Name or Material

Thapsigargin

Hazard Category

H315-H319-H334-H335

Hazard Statement

GHS H Statement
H334-H335-H315-H319
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause respiratory irritation.
Causes skin irritation.
Causes serious eye irritation.

Precautionary Statement

P261-P264b-P271-P280-P285-P302+P352-P304+P340-P305+P351+P338-P332+P313-P342+P311-P362-P501c

RTECSNumber

RH0325700

TSCA

No

Recommended Storage

Store at -20°C; Store under Nitrogen

SDS

Hazard Category

H315-H319-H334-H335

Hazard Statement

GHS H Statement
H334-H335-H315-H319
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
May cause respiratory irritation.
Causes skin irritation.
Causes serious eye irritation.

Precautionary Statement

P261-P264b-P271-P280-P285-P302+P352-P304+P340-P305+P351+P338-P332+P313-P342+P311-P362-P501c

RTECSNumber

RH0325700

TSCA

No

Recommended Storage

Store at -20°C; Store under Nitrogen

SDS

RUO – Research Use Only