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Thermo Scientific Chemicals Thiazolyl Blue tetrazolium bromide, 98%

Catalog No. AAL1193906
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Used in measurement of cell proliferation. Produces a yellowish solution that is converted to dark blue, water-insoluble MTT formazan by mitochondrial dehydrogenases of living cells.Thiazolyl Blue tetrazolium bromide is a dye used in measurement of cell proliferation. It is used as a direct indicator of cytotoxicity (such as for screening cancer drugs) and apoptosis. As an electron acceptor, it is utilized for studying nicotinamide adenine dinucleotide phosphate (NADP)-dependent dehydrogenases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Used in measurement of cell proliferation. Produces a yellowish solution that is converted to dark blue, water-insoluble MTT formazan by mitochondrial dehydrogenases of living cells.Thiazolyl Blue tetrazolium bromide is a dye used in measurement of cell proliferation. It is used as a direct indicator of cytotoxicity (such as for screening cancer drugs) and apoptosis. As an electron acceptor, it is utilized for studying nicotinamide adenine dinucleotide phosphate (NADP)-dependent dehydrogenases.

Solubility
Soluble in water, ethanol, 2-methoxyethanol and phosphate buffered saline.

Notes
Light, air and moisture sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

Chemical Identifiers

CAS

298-93-1

Molecular Formula

C18H16BrN5S

Molecular Weight (g/mol)

414.33

MDL Number

MFCD00011964,MFCD00066662

InChI Key

AZKSAVLVSZKNRD-UHFFFAOYSA-M

Synonym

thiazolyl blue, thiazolyl blue tetrazolium bromide, mmt tetrazolium, methylthiazoletetrazolium, mtt, thiazolyl blue monotetrazolium, thiazole blue, 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide, mtt van, unii-euy85h477i

PubChem CID

64965

ChEBI

CHEBI:53233

IUPAC Name

2-(3,5-diphenyltetrazol-2-ium-2-yl)-4,5-dimethyl-1,3-thiazole;bromide

SMILES

[Br-].CC1=C(C)N=C(S1)[N+]1=NC(=NN1C1=CC=CC=C1)C1=CC=CC=C1

Specifications

Melting Point

∽195°C (decomposition)

Odor

Odorless

Quantity

5 g

Beilstein

3825277

Sensitivity

Air, light, and moisture sensitive

Solubility Information

Soluble in water,ethanol,2-methoxyethanol and phosphate buffered saline.

Formula Weight

414.33

Percent Purity

98%

Chemical Name or Material

Thiazolyl Blue tetrazolium bromide

Hazard Category

H315-H319-H335-H341

Hazard Statement

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.

Precautionary Statement

P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362-P501c

EINECSNumber

206-069-5

RTECSNumber

XF8060000

TSCA

Yes

Recommended Storage

Ambient temperatures; Store under Nitrogen
SDS

RUO – Research Use Only

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