Thiazovivin, Tocris Bioscience™

Description

ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Thiazovivin is a selective, cell-permeable Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (IC50 = 0.5 μM). Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Thiazovivin improves the survival of human embryonic stem cells (hESCs) upon trypsinization and increases cell adhesion through the regulation of E-cadherin and significantly improves direct reprogramming efficiency. In combination with Valproic acid, sodium salt (Cat. No. 2815), Purmorphamine (Cat. No. 4551) and A 83-01 (Cat. No. 2939), Thiazovivin can be used to directly reprogram mouse embryonic fibroblasts into chemically induced neural stem cells.

Specifications

Chemical Identifiers

• CAS: 1226056-71-8
• Molecular Formula: C15H13N5OS
• Molecular Weight (g/mol): 311.363
• InChI Key: DOBKQCZBPPCLEG-UHFFFAOYSA-N
• Synonym: thiazovivin, n-benzyl-2-pyrimidin-4-ylamino thiazole-4-carboxamide, n-benzyl-2-pyrimidin-4-ylamino-1,3-thiazole-4-carboxamide, n-benzyl-2-pyrimidin-4-ylamino-thiazole-4-carboxamide, n-phenylmethyl-2-4-pyrimidinylamino-4-thiazolecarboxamide, pubchem24336, n-benzyl-2-pyrimidin-4-yl amino thiazole-4-carboxamide, benzyl-2-pyrimidin-4-ylamino thiazole-4-carboxamide, n-benzyl-2-pyrimidin-4-yl amino-1,3-thiazole-4-carboxamide, 4-thiazolecarboxamide, n-phenylmethyl-2-4-pyrimidinylamino
• PubChem CID: 46209426
• IUPAC Name: N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
• SMILES: C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3

• Quantity: 10 mg
• Formula Weight: 311.36
• Percent Purity: 98%
• Chemical Name or Material: Thiazovivin

Safety and Handling

Recommended Storage

Store at -20°C