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Tolfenamic acid, 99+%, Thermo Scientific Chemicals
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 µM.
Solubility
Soluble in water (slightly), acetone (∼10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (∼10 mg/ml) and ethanol (50 mg/ml).
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
Specifications
Color
White
Quantity
10 g
UN Number
UN2811
Merck Index
14,9513
Solubility Information
Soluble in water (slightly),acetone (∽10mg/ml),DMSO (52mg/ml at 25°C),methanol (∽10mg/ml) and ethanol (50mg/ml).
Formula Weight
261.7
Percent Purity
≥99%
Physical Form
Crystalline Powder
Chemical Name or Material
Tolfenamic acid
Hazard Category
H301
Hazard Statement
GHS H Statement
H301
Toxic if swallowed.
Precautionary Statement
P264b-P270-P301+P310-P330-P501c
DOTInformation
Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber
237-264-3
RTECSNumber
CB2687500
TSCA
No
Recommended Storage
Ambient temperatures
RUO – Research Use Only
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