TRAM 34, Tocris Bioscience™

Description

Potent and highly selective KCa3.1 channel blocker

Potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.

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Specifications

Chemical Identifiers

• CAS: 289905-88-0
• Molecular Formula: C22H17ClN2
• Molecular Weight (g/mol): 344.842
• InChI Key: KBFUQFVFYYBHBT-UHFFFAOYSA-N
• Synonym: tram-34, 1-2-chlorophenyl diphenylmethyl-1h-pyrazole, tram 34, 1-2-chlorophenyl-diphenylmethyl pyrazole, surecn41130, d03yvq, d05rlr, tram hplc , solid, 1-2-chlorophenyl-diphenyl-methyl pyrazole
• PubChem CID: 656734
• ChEBI: CHEBI:34990
• IUPAC Name: 1-[(2-chlorophenyl)-diphenylmethyl]pyrazole
• SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4

• Quantity: 10 mg
• Formula Weight: 344.84
• Percent Purity: >99%
• Chemical Name or Material: TRAM 34

Safety and Handling

Recommended Storage

Store at +4°C