Trichostatin A, Tocris Bioscience™

Description

Potent histone deacetylase inhibitor

Trichostatin A is a selective and potent inhibitor of class I and II histone deacetylases (HDAC) (Ki = 3.4 nM, IC50 values are 4.99 nM, 5.21 nM, 16.4 nM, 24.3 nM, 27.6 nM for HDAC1, 3, 6, 10 and 4, respectively). Trichostatin A induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Trichostatin A potently inhibits a range of breast cancer and melanoma cell lines (IC50 = 29-400 nM) and induces apoptosis in prostate cancer cells. In an animal model of Huntington's disease, inhibition of HDAC by Trichostatin A rescues memory deficits and increases expression of CREB/CBP target genes in mutant mice. Activates autophagy, increases vesicular transport of BDNF (Cat. No. 2837) and is active in vivo.

Specifications

Chemical Identifiers

• CAS: 58880-19-6
• Molecular Formula: C17H22N2O3
• Molecular Weight (g/mol): 302.37
• MDL Number: MFCD03848392
• InChI Key: RTKIYFITIVXBLE-WKWSCTOINA-N
• Synonym: trichostatin a, trichostatin a tsa, trichostatin, tsa, unii-3x2s926l3z, 2e,4e,6r-7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide, gnf-pf-1011, 2,4-heptadienamide, 7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxo, 7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide, r-e,e-7-4-dimethylamino phenyl-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
• PubChem CID: 444732
• ChEBI: CHEBI:46024
• IUPAC Name: (2E,4E)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
• SMILES: CC(\C=C(/C)\C=C\C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C

• Quantity: 1 mg
• Formula Weight: 302.37
• Percent Purity: 97%
• Chemical Name or Material: Trichostatin A

Safety and Handling

Recommended Storage

Desiccate at -20°C