Triethylamine trihydrofluoride, ca 37% HF, Thermo Scientific Chemicals

Triethylamine trihydrofluoride acts as a mild and selective fluorinating agent used in the synthesis of acid fluorides and alkyl fluorides. It is also used in the synthesis of vicinal difluorides from epoxides, 3-fluoroazetidine. It is utilized as a selective reagent for the cleavage of O-silyl groups in carbohydrates, nucleotides and cyanohydrins. It is actively involved in the electrochemical fluorodeiodination of alkyl iodides and fluorodesilylation in beta-lactams.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Triethylamine trihydrofluoride acts as a mild and selective fluorinating agent used in the synthesis of acid fluorides and alkyl fluorides. It is also used in the synthesis of vicinal difluorides from epoxides, 3-fluoroazetidine. It is utilized as a selective reagent for the cleavage of O-silyl groups in carbohydrates, nucleotides and cyanohydrins. It is actively involved in the electrochemical fluorodeiodination of alkyl iodides and fluorodesilylation in beta-lactams.

Solubility
Miscible with water, chloroform and hexanes.

Notes
Hygroscopic. Incompatible with strong oxidizing agents and glass.

Chemical Identifiers

CAS

73602-61-6

Molecular Formula

C6H18F3N

Molecular Weight (g/mol)

161.212

MDL Number

MFCD00043294

InChI Key

IKGLACJFEHSFNN-UHFFFAOYSA-N

Synonym

triethylamine trihydrofluoride, n,n-diethylethanamine trihydrofluoride, triethylammonium fluoride, ethanamine, n,n-diethyl-, trihydrofluoride, triethylamine trishydrofluoride, hydrogen fluoride in triethylamine, hf in triethylamine, triethylaminetrihydrofluoride, hydrogen fluoride triethylamine, ethanamine, n,n-diethyl-, hydrofluoride 1:3

PubChem CID

175505

IUPAC Name

N,N-diethylethanamine;trihydrofluoride

SMILES

CCN(CC)CC.F.F.F

Melting Point

-29°C

Density

0.99

Boiling Point

70°C (15 mmHg)

Flash Point

87°C (188°F)

Refractive Index

1.3915

Linear Formula

(CH₃CH₂)₃N·3HF

Quantity

5 g

UN Number

UN1790

Beilstein

5522945

Sensitivity

Hygroscopic

Solubility Information

Miscible with water,chloroform and hexanes.

Formula Weight

161.21

Assay

≈37% HF

Chemical Name or Material

Triethylamine trihydrofluoride

Hazard Category

H227-H300+H310+H330-H314-H335

Hazard Statement

GHS H Statement
H300-H310-H330-H314-H318-H227
Fatal if swallowed.
Fatal in contact with skin.
Fatal if inhaled.
Causes severe skin burns and eye damage.
Causes serious eye damage.
Combustible liquid.

Precautionary Statement

P210-P235-P260-P262-P264b-P270-P271-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c

DOTInformation

Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: HYDROFLUORIC ACID

EINECSNumber

277-550-5

TSCA

Yes

Recommended Storage

Ambient temperatures; Store under Nitrogen

SDS

Hazard Category

H227-H300+H310+H330-H314-H335

Hazard Statement

GHS H Statement
H300-H310-H330-H314-H318-H227
Fatal if swallowed.
Fatal in contact with skin.
Fatal if inhaled.
Causes severe skin burns and eye damage.
Causes serious eye damage.
Combustible liquid.

Precautionary Statement

P210-P235-P260-P262-P264b-P270-P271-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c

DOTInformation

Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: HYDROFLUORIC ACID

EINECSNumber

277-550-5

TSCA

Yes

Recommended Storage

Ambient temperatures; Store under Nitrogen

SDS

RUO – Research Use Only