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Trifluoroacetic acid, 99%, Thermo Scientific Chemicals
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Catalog No. AAL06374AE
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The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
The combination of properties like solubility in most of the solvents, volatility, catalytic property, and strong acidity with non-oxidizing nature makes it a widely used reagent in organic synthesis. Trifluoroacetic acid is an important building block in the synthesis of pharmaceuticals, agrochemicals and performance products. It is a precursor to many fluorinated compounds, and widely used in peptide synthesis and other organic transformations involving deprotection of t-BOC group. TFA finds use as an ion pairing agent in liquid chromatography, as a solvent in NMR spectroscopy and as a calibrant in mass spectrometry.

Solubility
Miscible with ether, acetone, ethanol, benzene, hexane and carbon tetrachloride.

Notes
Trifluoroacetic acid (TFA) is a stable, hygroscopic, volatile and low-boiling organic acid. Storage in a cool place is recommended.

Chemical Identifiers

CAS

76-05-1

Molecular Formula

C2HF3O2

Molecular Weight (g/mol)

114.02

MDL Number

MFCD00004169

InChI Key

DTQVDTLACAAQTR-UHFFFAOYSA-N

Synonym

trifluoroacetic acid, perfluoroacetic acid, trifluoroethanoic acid, trifluoroacetic acid, acetic acid, trifluoro, trifluoroaceticacid, cf3cooh, trifluoro acetic acid, trifluoro-acetic acid, kyselina trifluoroctova

PubChem CID

6422

ChEBI

CHEBI:45892

IUPAC Name

trifluoroacetic acid

SMILES

OC(=O)C(F)(F)F

Specifications

Melting Point

-15°C

Boiling Point

72°C to 73°C

Linear Formula

CF3CO2H

UN Number

UN2699

Beilstein

742035

Merck Index

14,9681

Solubility Information

Miscible with ether,acetone,ethanol,benzene,hexane and carbon tetrachloride.

Formula Weight

114.02

Percent Purity

99%

Density

1.48

Quantity

100 mL

Odor

Pungent

Refractive Index

1.284

Sensitivity

Hygroscopic

Chemical Name or Material

Trifluoroacetic acid

Hazard Category

H290-H314-H332-H335

Hazard Statement

GHS H Statement
H314-H332
Causes severe skin burns and eye damage.
Harmful if inhaled.

Precautionary Statement

P234-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P390-P501c

DOTInformation

Transport Hazard Class: 8; Packing Group: I; Proper Shipping Name: TRIFLUOROACETIC ACID

EINECSNumber

200-929-3

RTECSNumber

AJ9625000

TSCA

Yes

Recommended Storage

Ambient temperatures

RUO – Research Use Only

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