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TRO 19622, Tocris Bioscience™

Catalog No. p-4784722 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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Description

Binds voltage-dependent anion channel (VDAC)

Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening.

Chemical Identifiers

CAS 22033-87-0
Molecular Formula C27H45NO
Molecular Weight (g/mol) 399.663
InChI Key QNTASHOAVRSLMD-GYKMGIIDSA-N
Synonym olesoxime, cholest-4-en-3-one, oxime
PubChem CID 76971721
IUPAC Name N-[(8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-ylidene]hydroxylamine
SMILES CC(C)CCCC(C)C1CCC2C1(CCC3C2CCC4=CC(=NO)CCC34C)C

Specifications

Quantity 10 mg
Formula Weight 399.65
Percent Purity >98%
Chemical Name or Material TRO 19622

Safety and Handling

Recommended Storage Desiccate at +4°C
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