Thermo Scientific Chemicals U0126, ≥99%

Selective inhibitor of mitogen-activated protein kinases MEK-1 and MEK-2

U0126, is used as a selective MAP Kinase Kinase (MKK, MEK) inhibitor. U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chemical Identifiers

CAS

109511-58-2

Molecular Formula

C₁₈H₁₆N₆S₂, C18H16N6S2

Synonym

1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene

Quantity

100 mg

Description

White

Content And Storage

-30°C to -10°C

For Use With (Application)

Selective inhibitor of mitogen-activated protein kinases MEK-1 and MEK-2

Formula Weight

380.49g/mol

Solubility

Soluble in DMSO; Poorly soluble in ethanol and water

Product Type

Signal Transduction Reagent

Form

Powder

InChI Key

DVEXZJFMOKTQEZ-JYFOCSDGSA-N

SMILES

N\C(SC1=CC=CC=C1N)=C(\C#N)/C(/C#N)=C(\N)SC1=CC=CC=C1N

IUPAC Name

(2Z,3Z)-bis({amino[(2-aminophenyl)sulfanyl]methylidene})butanedinitrile

Molecular Weight (g/mol)

380.49

Assay

≥99%

Recommended Storage

Store at -20°C

SDS

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only