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  7. WR 1065, Tocris Bioscience™

WR 1065, Tocris Bioscience™

Catalog No. p-4784805 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

p53 activator. Also ROS scavenger

Cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway. Activates p21waf-1 and MDM2, represses transcription of Myc and thymidine kinase, and inhibits DNA topoisomerase IIα. Induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Also exhibits broad spectrum antiviral activity in vitro.

Chemical Identifiers

CAS 14653-77-1
Molecular Formula C5H16Cl2N2S
Molecular Weight (g/mol) 207.16
MDL Number MFCD00460339
InChI Key XDRLRDHLCIFZIW-UHFFFAOYSA-N
Synonym wr 1065 hydrochloride, amifostine thiol dihydrochloride, unii-le9vv16szw, wr-1065 dihydrochloride, 2-3-aminopropyl amino ethanethiol dihydrochloride, 2-3-aminopropylamino ethanethiol dihydrochloride, le9vv16szw, ethanethiol, 2-3-aminopropyl amino-, dihydrochloride, 2-3-aminopropyl amino ethanethiol 2hcl
PubChem CID 146169
IUPAC Name dihydrogen 2-[(3-aminopropyl)amino]ethane-1-thiol dichloride
SMILES [H+].[H+].[Cl-].[Cl-].NCCCNCCS

Specifications

Quantity 10 mg
Formula Weight 207.16
Percent Purity >98%
Chemical Name or Material WR 1065

Safety and Handling

Recommended Storage Desiccate at -20°C
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