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Y-26763, Tocris Bioscience™

Catalog No. 207650 Shop All R&D Systems Products
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Kir6 (KATP) channel opener

Y-26763 is a Kir6 (KATP) channel opener and active metabolite of Y-27152. Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.

Chemical Identifiers

CAS

127408-31-5

Molecular Formula

C14H16N2O4

Molecular Weight (g/mol)

276.292

InChI Key

IWTCFIIOUXJOOV-OLZOCXBDSA-N

Synonym

unii-q9f3xv8a6x, q9f3xv8a6x, +-3s,4r-n-acetyl-n-hydroxy amino-6-cyano-3,4-dihydro-2,2-dimethyl-2h-1-benzopyran-3-ol, n-3s,4r-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2h-1-benzopyran-4-yl-n-hydroxyacetamide, acetamide, n-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2h-1-benzopyran-4-yl-n-hydroxy-, 3s-trans, n-3s,4r-6-cyano-3-hydroxy-2,2-dimethylchroman-4-yl-n-hydroxyacetamide, acetamide,n-3s,4r-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2h-1-benzopyran-4-yl-n-hydroxy, n-3s,4r-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-1-benzopyran-4-yl-n-hydroxyacetamide, d05gpx, n-3s,4r-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl-n-hydroxyacetamide

PubChem CID

121878

IUPAC Name

N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-hydroxyacetamide

SMILES

CC(=O)N(C1C(C(OC2=C1C=C(C=C2)C#N)(C)C)O)O

Specifications

Quantity

50 mg

Formula Weight

276.29

Percent Purity

>98%

Chemical Name or Material

Y-26763

Recommended Storage

Store at Room Temperature
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