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YC 1, Tocris Bioscience™

Catalog No. p-4817104 Shop All R&D Systems Products
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

Nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of washed rabbit platelets (IC50 = 14.6 μM); induces relaxation in denuded phenylephrine-contracted rabbit aortic rings (EC50 = 1.9 μM). Also displays antiproliferative activity in vitro and in vivo by inducing G1 cell cycle arrest in two human hepatocellular carcinoma (HCC) cell lines, and in HCC xenografts in athymic SCID mice. Exhibits low cytotoxicity in non-malignant cells.

Chemical Identifiers

CAS 170632-47-0
Molecular Formula C19H16N2O2
Molecular Weight (g/mol) 304.35
MDL Number MFCD06407798
InChI Key OQQVFCKUDYMWGV-UHFFFAOYSA-N
Synonym yc-1, lificiguat, yc 1, 3-5'-hydroxymethyl-2'-furyl-1-benzylindazole, unii-515cc1wpte, 515cc1wpte, 3-5'-hydroxymethyl-2'-furyl-1-benzyl indazole, 5-1-benzyl-1h-indazol-3-yl furan-2-yl methanol, 5-1-phenylmethyl-1h-indazol-3-yl-2-furanmethanol, 2-furanmethanol,5-1-phenylmethyl-1h-indazol-3-yl
PubChem CID 5712
IUPAC Name [5-(1-benzyl-1H-indazol-3-yl)furan-2-yl]methanol
SMILES OCC1=CC=C(O1)C1=NN(CC2=CC=CC=C2)C2=CC=CC=C12

Specifications

Quantity 10 mg
Formula Weight 304.34
Percent Purity >99%
Chemical Name or Material YC 1

Safety and Handling

Recommended Storage Store at Room Temperature
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