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YM 58483, Tocris Bioscience™

Catalog No. 393950 Shop All R&D Systems Products
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Inhibitor of SOCE in non-excitable cells

YM 58483 is a blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin -induced sustained Ca2+ influx (IC50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro.

Chemical Identifiers

CAS

223499-30-7

Molecular Formula

C15H9F6N5OS

Molecular Weight (g/mol)

421.321

InChI Key

XPRZIORDEVHURQ-UHFFFAOYSA-N

Synonym

btp2, crac channel inhibitor, btp2, n-4-3,5-bis trifluoromethyl pyrazol-1-yl phenyl-4-methylthiadiazole-5-carboxamide, n-4-3,5-bis trifluoromethyl-1h-pyrazol-1-yl phenyl-4-methyl-1,2,3-thiadiazole-5-carboxamide, maybridge3_006679, d0jv2p, btp-2, ym hplc, 4-methyl-4'-3,5-bis trifluoromethyl-1h-pyrazol-1-yl-1,2,3-thiadiazole-5-carboxanilide, 1,2,3-thiadiazole-5-carboxamide,n-4-3,5-bis trifluoromethyl-1h-pyrazol-1-yl phenyl-4-methyl

PubChem CID

2455

IUPAC Name

N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide

SMILES

CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F

Specifications

Quantity

50 mg

Formula Weight

421.32

Percent Purity

>99%

Chemical Name or Material

YM 58483

Recommended Storage

Store at +4°C
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