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Zoniporide dihydrochloride, Tocris Bioscience™

Catalog No. 272750 Shop All R&D Systems Products
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Selective NHE1 inhibitor

Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Chemical Identifiers

CAS

241799-10-0

Molecular Formula

C17H18Cl2N6O

Molecular Weight (g/mol)

393.272

InChI Key

ARZNPJAGKWHEHT-UHFFFAOYSA-N

Synonym

zoniporide dihydrochloride, 1-quinolin-5-yl-5-cyclopropyl-1h-pyrazole-4-carbonyl guanidine dihydrochloride

PubChem CID

22267855

IUPAC Name

5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide;dihydrochloride

SMILES

C1CC1C2=C(C=NN2C3=CC=CC4=C3C=CC=N4)C(=O)N=C(N)N.Cl.Cl

Specifications

Quantity

50 mg

Formula Weight

393.27

Percent Purity

>99%

Chemical Name or Material

Zoniporide dihydrochloride

Recommended Storage

Store at -20°C
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