Whole Blood Cells
Cayman Chemical 10 ZHeptadecenoIc ACD meth
A histamine H1 receptor antagonist (Ki 1.3 nM) selective for histamine H1 over H2 and H3 receptors (Kis 49 and 12.43 UM respectively) as well as a1- a2- and B1-adrenergic and dopamine D1 and D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 at 10 UM inhibits histamine-induced phosphoinositide turnover and intracellular calcium mobilization in primary HCECs (IC50s 1.6 and 2.9 nM respectively) inhibits histamine-stimulated secretion of IL-6 IL-8 and GM-CSF by primary HCECs (IC50s 2.23 3.42 and 1.50 nM respectively) ocular application of emedastine prior to histamine challenge inhibits vascular permeability in guinea pigs
Cayman Chemical 10 ZHeptadecenoIc ACD meth
A histamine H1 receptor antagonist (Ki 1.3 nM) selective for histamine H1 over H2 and H3 receptors (Kis 49 and 12.43 UM respectively) as well as a1- a2- and B1-adrenergic and dopamine D1 and D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 at 10 UM inhibits histamine-induced phosphoinositide turnover and intracellular calcium mobilization in primary HCECs (IC50s 1.6 and 2.9 nM respectively) inhibits histamine-stimulated secretion of IL-6 IL-8 and GM-CSF by primary HCECs (IC50s 2.23 3.42 and 1.50 nM respectively) ocular application of emedastine prior to histamine challenge inhibits vascular permeability in guinea pigs