Goat Secondary Antibodies
Goat Secondary Antibodies
Cayman Chemical TaurohyocholIc AcIdodIM10mg
A bicyclic guanidine base that can be used as a catalyst for a variety of base-mediated organic transformations
Cayman Chemical D-CycloserIn 500mg
An apoptosis inducer that inhibits the mitochondrial F1FO ATPase (Ki 4-5 UM) selectively kills transformed glial cells without significantly affecting untransformed cells
Cayman Chemical L-SelenocystIn 50mg
A potent selective ATP-competitive inhibitor of c-Met (IC50 20 nM) induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines
Cayman Chemical ANTIBODY AP-III-a4 10mg
A selective inhibitor of PFKFB3 (IC50 207 nM) rapidly induces apoptosis in transformed cells suppresses glucose uptake and growth of Lewis lung carcinomas in syngeneic mice and yields antitumor effects in human xenograft models of cancer in athymic mice
Cayman Chemical RabbIt ntI-Goat IgGDyLIght 1mg
A selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki 149 UM) inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-RasG12V-transformed NIH 3T3 cells (IC50 1.4-2 UM)
Cayman Chemical Goat ntI-RabbIt IgGSureLIg 1mg
A selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki 149 UM) inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-RasG12V-transformed NIH 3T3 cells (IC50 1.4-2 UM)
Cayman Chemical Goat ntI-RabbIt IgGDyLIght 1mg
A selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki 149 UM) inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-RasG12V-transformed NIH 3T3 cells (IC50 1.4-2 UM)
Cayman Chemical THUNDRTotal JNK123 TRFR 4800
A DOT1L inhibitor (IC50 0.3 nM) selective for DOT1L over a panel of 12 additional protein methyltransferases DNMT1 and a panel of 29 receptors and ion channels reduces H3K79me2 levels in MCF-10A breast cancer cells (IC50 8.8 nM) selectively reduces the viability of isolated human cord blood cells transformed with an MLL-AF9 fusion oncogene over those transformed with a TLS-ERG fusion oncogene at 1 and 5 UM adoptive transfer of isolated human CD3 T cells pre-incubated with SGC0946 (0.5 UM) prevents weight loss increases survival and reduces hepatic and colonic lymphocyte infiltration in a xenogeneic mouse model GVHD
Cayman Chemical THUNDRTotal JNK123 TRFR 9600
A DOT1L inhibitor (IC50 0.3 nM) selective for DOT1L over a panel of 12 additional protein methyltransferases DNMT1 and a panel of 29 receptors and ion channels reduces H3K79me2 levels in MCF-10A breast cancer cells (IC50 8.8 nM) selectively reduces the viability of isolated human cord blood cells transformed with an MLL-AF9 fusion oncogene over those transformed with a TLS-ERG fusion oncogene at 1 and 5 UM adoptive transfer of isolated human CD3 T cells pre-incubated with SGC0946 (0.5 UM) prevents weight loss increases survival and reduces hepatic and colonic lymphocyte infiltration in a xenogeneic mouse model GVHD
Cayman Chemical THUNDRTotal JNK123 TRFR 2400
A DOT1L inhibitor (IC50 0.3 nM) selective for DOT1L over a panel of 12 additional protein methyltransferases DNMT1 and a panel of 29 receptors and ion channels reduces H3K79me2 levels in MCF-10A breast cancer cells (IC50 8.8 nM) selectively reduces the viability of isolated human cord blood cells transformed with an MLL-AF9 fusion oncogene over those transformed with a TLS-ERG fusion oncogene at 1 and 5 UM adoptive transfer of isolated human CD3 T cells pre-incubated with SGC0946 (0.5 UM) prevents weight loss increases survival and reduces hepatic and colonic lymphocyte infiltration in a xenogeneic mouse model GVHD
Cayman Chemical 15 R 19 Rhydroxy Prostagla
An aminoglycoside antibiotic active against E. coli (MIC 150 Ug/ml) cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis has commonly been used in molecular and cell biology applications to select for transformed cells expressing the E. coli hygromycin resistance genes hyg or hph
Cayman Chemical LactobIonIc AcId 25g
An a2-adrenergic receptor antagonist (Kd 2 6 UM) and an L-type calcium channel blocker (IC50 17 UM) well-known for its coronary vasodilator effects inhibits K-Ras plasma membrane localization (IC50 9 64 UM) blocking the proliferation of K-Ras-transformed tumor cells
Cayman Chemical LactobIonIc AcId 50g
An a2-adrenergic receptor antagonist (Kd 2 6 UM) and an L-type calcium channel blocker (IC50 17 UM) well-known for its coronary vasodilator effects inhibits K-Ras plasma membrane localization (IC50 9 64 UM) blocking the proliferation of K-Ras-transformed tumor cells
Cayman Chemical 7- -HydroxyethyltheophylIn 50g
A turn-on fluorescent probe to detect hypoxia transformed into a highly fluorescent molecule in the presence of nitroreductase a marker of hypoxia selective for nitroreductase over a variety of bioanalytes including glutathione ascorbic acid and H2O2 has been used to detect hypoxia in A549 human lung carcinoma cells at 1 UM ex/em 454/520 nm respectively
Cayman Chemical 7- -HydroxyethyltheophylIn 10g
A turn-on fluorescent probe to detect hypoxia transformed into a highly fluorescent molecule in the presence of nitroreductase a marker of hypoxia selective for nitroreductase over a variety of bioanalytes including glutathione ascorbic acid and H2O2 has been used to detect hypoxia in A549 human lung carcinoma cells at 1 UM ex/em 454/520 nm respectively
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