Cayman Chemical Progesterone 5g
A 5-LO inhibitor (IC50 15 nM) selective for 5-LO over 12-LO and 15-LO (IC50s 500 and 300 nM respectively) inhibits A23187-induced 5-LO product formation in isolated human PMNs monocytes and whole blood (IC50s 0.5 0.45 and 1.5 UM respectively) increases survival in a mouse model of PAF-induced lethal shock at 3.5 mg/kg reduces pleural levels of LTB4 in a rat model of carrageenan-induced pleurisy