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Tocris Bioscience™ SCH 51344
Potent MTH1 inhibitor
Supplier: Tocris Bioscience™ 5280/50
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Description
SCH 51344 is a potent MTH1 inhibitor (Kd = 49 nM). Inhibits Ras-induced malignant transformation and increases α-actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.Specifications
| >99% | |
| SCH 51344 | |
| SCH 51344 |
| 50 mg | |
| 316.35 |
Product Title
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