Guinea Pig Whole Blood
Guinea Pig Whole Blood
Cayman Chemical GlycoursodeoxycholIc ACD Max
Immunogen Peptide from the C-terminal region of human PLCB2 Host Rabbit Species Reactivity ( ) Human Non-human Primate Applications IHC IF MW 135 kDa
Cayman Chemical ArachIdonIc ACD 1 2 3 4 513
A pan Akt inhibitor (Ki 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation slows the progression of Akt-dependent tumors in vivo concomitantly increases Akt Thr308 and Ser473 phosphorylation via a rapid feedback reaction
Cayman Chemical 8 Z 14 ZEIcosadIenoIc ACD
A paramagnetic nitroxide spin label featuring a methanethiosulfonate group for site-directed spin labeling particularly through disulfide linkages with cysteine residues on proteins
Cayman Chemical DocosahexaenoIc ACD Alkyn
A long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture included in media to enhance the survival of human embryonic stem cells or drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem cells
Cayman Chemical DotrIacontnoIc ACD methyl100mg
An orally bioavailable broad-spectrum triazole antifungal agent completely inhibits growth of T. rubrum M. audouini M. canis and T. verrucosum as well as some C. albicans and A. fumigatus strains and other fungi (100 g/ml) bacteriostatic against E. coli P. aeruginosa S. aureus and S. pyogenes (100 g/ml) eliminates vaginal C. albicans candidiasis infection in 97 of rats (1 topical) eliminates vaginal C. albicans candidiasis infection in 50 of rats (10 mg/kg oral) decreases synthesis of 14a-desmethyl sterols and increases synthesis of methylated sterols in C. albicans (IC50 3 nM)
Cayman Chemical 2Hydroxy Faty ACD Methyl10mg
An adenosine A2B receptor antagonist (Ki 53.4 nM) selective for A2B over A1 and A2A receptors which have Ki values of 2200 and 24000 nM respectively selective for A2B over the A3 receptor which is inhibited only 14 at a concentration of 10 UM pre-treatment of rat trachea reduces relaxation induced by repeated dosing of the non-selective adenosine agonist NECA
Cayman Chemical PRfluorotetradecnoIc ACD 500mg
An antagonist of mGluR1 and mGluR2 selective for mGluR1 and mGluR2 over mGluR6 at 1 mM inhibits L-glutamate-induced increases in InsPs in CHO cells expressing mGluR1 and prevents forskolin-induced decreases in cAMP in CHO cells expressing mGluR2 at 1 mM intraplantar administration reduces glutamate-induced paw licking in a mouse model of nociceptive pain at 1-10 nmol/paw
Cayman Chemical 3 3DIthIodIpropIonIc ACD d
An inhibitor of MMP-9 zymogen activation (IC50 440 nM) selective for MMP-9 over MMP-1 MMP-2 and MMP-3 zymogen activation at 10 M inhibits invasion of HT-1080 cells in a MatrigelTM assay (IC50 1 M) reduces disease severity in a mouse model of EAE at 10 and 30 mg/kg twice per day
Sigma Aldrich Fine Chemicals Biosciences Alsevers Solution liqids500ML
Alsevers SOLUTIONon liqids500ML
Cayman Chemical 7 12DIketolIthocholIc ACD
A carotenoid with hepatoprotective activity inhibits TGF-b-induced activation of hepatic stellate cells (IC50 186.34 UM) reduces hepatic collagen deposition and TBARS levels as well as serum AST and ALP activity in a rat model of bile duct ligation-induced hepatic fibrosis at 25 mg/kg reduces hepatic steatosis inflammation and fibrosis in a model of NASH induced by a methionine choline-deficient diet in HBV transgenic mice
Cayman Chemical 3 3SulfInyldIpropnoIc ACD
A peptide substrate for PKC selective for PKC over PKA CK1 CK2 phosphorylase kinase and CaMKII has been used to monitor PKC activity in primary human renal artery smooth muscle cells
Cayman Chemical 4HydroxyphenylglyoxylIc ACD
A dual inhibitor of p70S6K and Akt1 (IC50s 1.1 and 4 nM respectively) selective for p70S6K and Akt1 over Aurora B kinase (IC50 170 nM) as well as a panel of 265 kinases at 1 UM inhibits PKA MSK1 MSK2 PKG1a PKG1B and PRKX reduces tumor volume in A549 and MiaPaCa-2 mouse xenograft models at doses of 20 or 30 mg/kg respectively
Cayman Chemical ProstatIc ACD Phosphatsem
A peptide antagonist of PAR4 inhibits platelet aggregation induced by AYPGKF-NH2 in washed isolated rat platelets (IC50 95-190 UM) induces relaxation of isolated rat aortic rings precontracted with phenylephrine and contraction of isolated rat gastric longitudinal muscle strips (EC50s 64 and 1 UM respectively) inhibits thrombin-induced migration of primary HCC cells at 400 UM reduces myocardial infarct size as a percentage of the area at risk ex vivo in an isolated rat heart model of ischemia-reperfusion injury