DNA Reagents
Chemgenes Corporation 2'-O-METHYL ADENOSINE (N-10G
2'-O-Methyl Adenosine(n-bz) 3'-lcaa CPG 500A, 10G
![Revvity Health Sciences Inc Adenosine 5'-Triphosphate, Tetrasodium Salt, [2,8-<sup>3</sup>H]-, 1 mCi (37 MBq)](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502811074.jpg-250.jpg)
Revvity Health Sciences Inc Adenosine 5'-Triphosphate, Tetrasodium Salt, [2,8-3H]-, 1 mCi (37 MBq)
Adenosine 5'-Triphosphate, Tetrasodium Salt, [2,8-3H]-, 1 mCi (37 MBq)
Enzo Life Sciences GPA GUANYLYL- 3 5-ADEN 1UMOL
GpA:Guanylyl- (3' −> 5')- adenosine ( GpA ), sodium salt, 1umol, 103192-56-9
Enzo Life Sciences PG 2 5 PA 5- PHOSPHOGUAN 1UMOL
pG(2’5’)pA : 5'- Phosphoguanylyl- (2' −> 5')- adenosine ( pG(2',5')pA / 5'-p(rG)(2',5')p(rA) ), sodium salt, 1umol
Zymo Research Corporation E. coli Non-Methylated Genomic DNA (5 μg/ 20 μl)
E. coli Non-methylated Genomic DNA for use as a negative control for epigenetic experiments requiring DNA containing zero background levels of cytosine and adenosine methylation. Substrate for DNA methylation-sensitive restriction enzyme digestions.
Invivogen 2'3'-CGAMP
2’3’-cGAMP (cyclic [G(2’,5’)pA(3’,5’)p]) is produced in mammalian cells by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. 2’3’-cGAMP is also referred to as “noncanonical“ cGAMP due to the presence of the atypical 2’-5’ phosphodiester linkage between the guanosine and the adenosine. Similar to the canonical 3’3’-cGAMP, 2’3’-cGAMP serves as a second messenger to activate innate immune responses by binding to STING (stimulator of IFN genes) and subsequently inducing the TBK1-IRF3-dependent production of IFN-β [1]. Structural and functional studies revealed that noncanonical 2’3’-cGAMP is distinct from the canonical 3’3’-cGAMP produced by bacteria [2,3]. 2'3'-cGAMP binds to STING with a much greater affinity than 3'3'-cGAMP [1]. Certain variants of STING are able to distinguish between noncanonical and canonical cGAMP [2]