Hypoxia occurs in tumors as a result of the poor ability of their disorganized vascular networks to deliver blood borne oxygen. HypoxiSense680 fluorescent imaging agent detects the tumor cell surface expression of carbonic anhydrase 9 (CA IX) protein, which increases in hypoxic regions within many tumors, especially in cervical, colorectal, non-small cell lung tumors. Pairing HypoxiSense with optical fluorescent imaging technology allows you to image and quantitate tumor sub-regions undergoing hypoxia-related changes, non-invasively and in vivo. HypoxiSense in vivo imaging reagent is ideally suited for detecting hypoxia-induced changes in CA IX expression during: Imaging in vivo mouse and rat tumors Assessing therapeutic efficacy in drug screening of tumor models Fluorescence microscopy of disease tissues For the first time, hypoxia can be measured non-invasively in living mice and rats, as well as in ex vivo tissue samples. It's the perfect solution for the in vivo hypoxia researche