A sesquiterpene alcohol with diverse biological activities a PAM of GABAA receptors that potentiates GABA-induced currents in hippocampal neurons reduces activation of proinflammatory NF-KB and profibrotic TGF-B1/SMAD signaling pathways in RAW 264 7 cells stimulated with cigarette smoke extract from 1-200 g/ml inhibits proliferation of and induces apoptosis in LoVo and SW480 colorectal cancer cells reduces tumor volume in a LoVo mouse xenograft model from 20-80 mg/kg increases the rate of wound closure in rats with streptozotocin-induced diabetes