Mass-Tagged Crosslinkers
Mass-Tagged Crosslinkers
Cayman Chemical SulfamethIzole-d4 10mg
An inhibitor of LMW-PTPA (IC50 0.8 UM) selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by 50 at 40 UM increases insulin-induced insulin receptor phosphorylation in HepG2 cells at 10 UM improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity at 50 mg/kg per day
Cayman Chemical 3-CholIc AcId-d4 5mg
An alkaloid reduces proliferation of SW480 colon adenocarcinoma cells in a dose- and time-dependent manner decreases viability of HL-60 leukemia cells (IC50s 47 88 23 85 and 18 87 M at 24 48 and 72 hours post-treatment respectively) induces cell cycle arrest at the G1/S phase and decreases PI3K Akt and mTOR gene expression in a dose-dependent manner inhibits GABA and GABA-activated benzodiazepine binding to rat brain membranes (IC50s 57 and 101 M respectively) induces clonic and tonic convulsions in mice at 5 2 mg/kg
Cayman Chemical ClofIbrIc AcId-d4 5mg
A deoxyribonucleoside phosphorylated by deoxycytidine kinase in the cytosol or TK2 in mitochondria to form dCMP oral administration in combination with deoxythymidine delays disease onset and increases lifespan in a mouse model of TK2 deficiency
Cayman Chemical AlolIthocholIc AcId-d4 5mg
A linoleic acid metabolite induces chemotaxis increases the levels of CCR9 and CXCR4 and inhibits IL-6 release in primary human monocytes inhibits CD3a- and CD28-induced proliferation of isolated human peripheral blood lymphocytes at 25 Ug/ml
Cayman Chemical DMABA-d4 NHS ester 10mg
A stable analog of 9-THC and AEA exhibits high-affinity for the CB1 and CB2 receptors (Ki 210 and 30 nM respectively) behaves primarily as a CB1 receptor partial agonist and a CB2 receptor neutral antagonist in vitro
Cayman Chemical DMABA-d4 NHS ester 1mg
An internal standard for the quantification of abnormal cannabidiol by GC- or LC-MS intended for research and forensic applications
Cayman Chemical N-NItrosonrnIcotIn-d4 5mg
An analytical reference standard categorized as an imidazothiazole used as a cutting agent with cocaine intended for research and forensic applications
Cayman Chemical SulfamethazIn-d4 10mg
A potent 5-HT2C receptor agonist selective for human 5-HT2C and rat 5-HT2C over human 5-HT2A 5-HT2B and rat 5-HT2A receptors in a FLIPR assay (EC50s 0 11 0 06 153 65 3 and 119 nM respectively) as well as human dopamine D2 histamine H1 and a1- and a2-adrenergic receptors (Kis 872 828 217 and 956 nM respectively) inhibits the conditioned avoidance response hyperactivity induced by PCP and D-amphetamine and spontaneous locomotor activity in rats (ED50s 4 8 2 4 2 9 and 2 mg/kg respectively) reduces reinstatement of drug-seeking behavior in cocaine-primed rats (0 01-1 g/0 2 l/side in the central amygdala)
Cayman Chemical CInabarInIc AcId-d4 5mg
A benzyolated derivative of cytidine a substrate of UCK1 and UCK2 has been used in the synthesis of 2ʹ-OH protecting groups for solid-phase RNA synthesis and synthetic oligonucleotides for UV light-induced and targeted gene silencing in zebrafish embryos
Cayman Chemical LInoleIc AcId-d4 5mg
An inhibitor of uridine phosphorylase (apparent Ki 2.268 UM) has been used as a building block in the synthesis of compounds with anticancer or antiviral activities
Cayman Chemical DeoxycholIc AcId-d4 5mg
An intermediate in the synthesis of cysteine that is produced from homocysteine and serine by the action of cystathionine-b-synthase excess cystathionine in the urine is a hallmark of cystathioninuria
Cayman Chemical UrsocholIc AcId-d4 5mg
A positive allosteric modulator of AMPA receptors increases the release of norepinephrine induced by AMPA but not NMDA or kainic acid in rat hippocampal slices increases amplitude and duration of primed field EPSPs in rat hippocampal slices (EC50s 480 and 590 UM respectively) enhances memory in two-odor discrimination and radial maze tests as well as in the Morris water maze in rats at a 120 mg/kg
Cayman Chemical MIltefosIn-d4 10mg
A phospholipid has been used to study the interaction between water and the phosphocholine headgroup in aqueous solutions
Cayman Chemical MoclobemIde-d4 25mg
An ASIC3 activator (EC50 67 UM for evoking rapid inward currents in ASIC3-expressing CHO cells at neutral pH) an inhibitor of the GABAA receptor (IC50 0.39 UM in primary rat hippocampal neurons) increases paw licking time in Asic3 / and to a lesser extent Asic3-/- mice at 100 UM