DLin-MC3-DMA is an ionizable cationic lipids used in the formulation of lipid nanoparticles (LNPs) encapsulating siRNA, mRNA, plasmid DNA, and other nucleic acids for delivery in vitro or in vivo. DLin-MC3-DMA, when used in combination with other lipids, has been shown to be an especially potent vehicle for siRNA delivery.Key application(s): siRNA delivery, plasmid DNA delivery, mRNA delivery