Isotype Controls and Standards
Isotype Controls and Standards
Cayman Chemical PD 0332991hydrochlorIde 25mg
An analog of latanoprost (free acid) that contains a hydrogen sulfide releasing component reduces IOP better than latanoprost in a rabbit model of glaucoma
Enzo Life Sciences Neutralizing reagent, (5ml)
Neutralizing buffer for low pH solutions; for use with cyclic nucleotide and isoprostane kits. Formulation: Liquid. A high pH buffer to neutralize 0.1M hydrogen chloride in an EIA system; for use with cyclic nucleotide and isoprostane kits. Long Term Storage: Ambient.
Cayman Chemical QuInacrIn mustardhydroCLO 25mg
An oxidized form of ascorbic acid inhibits hydrogen peroxide-induced cell death in murine astrocytes by approximately 74 and 83 at 0 5 and 1 mM respectively increases GPX and glutathione reductase activity and inhibits ROS production in hydrogen peroxide-treated astrocytes at 1 mM increases cerebral blood flow and reduces infarct volume and mortality in a mouse model of cerebral ischemia-reperfusion injury induced by transient MCAO when administered prior to ischemia at 40 and 250 mg/kg reduces infarct volume in a permanent MCAO mouse model when administered pre- or post-ischemia at 250 and 500 mg/kg respectively
Cayman Chemical LCysteInsulfInIc AcIdhydr 25mg
An oxidized form of ascorbic acid inhibits hydrogen peroxide-induced cell death in murine astrocytes by approximately 74 and 83 at 0 5 and 1 mM respectively increases GPX and glutathione reductase activity and inhibits ROS production in hydrogen peroxide-treated astrocytes at 1 mM increases cerebral blood flow and reduces infarct volume and mortality in a mouse model of cerebral ischemia-reperfusion injury induced by transient MCAO when administered prior to ischemia at 40 and 250 mg/kg reduces infarct volume in a permanent MCAO mouse model when administered pre- or post-ischemia at 250 and 500 mg/kg respectively
Cayman Chemical Dexamethason PalmItate 25mg
An AhR agonist activates transcription of CYP1A1 at 1 and 10 UM in HepG2 cells inhibits hydrogen peroxide-induced apoptosis as well as increases the activity of CAT and SOD and decreases the activity of MDA in SH-SY5Y cells at 10 UM has been used as a positive control for the induction of AhR transcriptional activity
Cayman Chemical ANTIBODY Dnp-GPLG 1mg
An inhibitor of FAF1 inhibits chemical hypoxia-induced apoptosis in H9c2 cardiomyocytes and hydrogen peroxide-induced cell death in SH-SY5Y cells at 10 and 20 M respectively reduces decreases in striatal dopamine transporter activity in a mouse model of MPTP-induced Parkinsons disease at 20 mg/kg per day
Cayman Chemical BortezomIb ImpurIty A 25mg
A peptide fragment of prosaposin and GPR37L1 and GPR37 agonist activates ERK signaling in HEK293T cells expressing GPR37L1 or GPR37 (EC50s 5 and 7 nM respectively) protects primary mouse astrocytes from hydrogen peroxide-induced cell death at 100 nM reduces allodynia in a variety of rat peripheral pain models at 4 mg/kg and prevents formalin-induced paw allodynia at 1 mg/kg
Cayman Chemical 3-DeoxygunosIn 25mg
A chemiluminescent probe used to detect superoxide production by enzymatic and cellular sources produces similar chemiluminescence in isolated aortic and cardiac tissues from wild-type and Nox1-Nox2-Nox4 triple knockout mice suggesting that it is not selective for NADPH-based ROS production reacts with hydrogen peroxide without generating free radical intermediates a fluorescent chloride-sensitive indicator with its fluorescence being quenched by chloride (ex/em 455/505 nm respectively)
Cayman Chemical Lophathrum gracl sovtxn 25mg
A bacterial metabolite scavenges ABTS radicals in a cell-free assay at 50-150 UM and decreases hydrogen peroxide-induced MDA levels in rat striatal membranes (IC50 180 UM) decreases increases in MDA levels induced by amyloid B (1-42) in PC12 cells decreases ischemia-induced increases in cell death of pyramidal neurons and levels of HNE and GFAP in the hippocampal CA1 region in gerbils at 10 mg/kg per day
Cayman Chemical TrIgonlIn-d3chlorIde 25mg
A pentacyclic triterpenoid induces cell cycle arrest at the G0/G1 phase and inhibits proliferation of MCF-7 human breast cancer cells in a concentration-dependent manner prevents hydrogen peroxide-induced DNA damage in the same cells induces relaxation of phenylephrine- or potassium chloride-precontracted aortic rings isolated from spontaneously hypertensive rats at 100 UM inhibits ovalbumin-induced BALF eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma
Cayman Chemical 3-AzIdo-2 3-dIdeoxyurIdIn 25mg
A steroid glycoside induces apoptosis in and reduces TGF-B1-induced migration of MDA-MB-231 human breast cancer cells at 2 5 5 or 10 UM inhibits hydrogen peroxide-induced ROS production in RAW 264 7 cells at 10 and 100 UM peritoneal neutrophil infiltration in a mouse model of zymosan A-induced peritonitis at 1 mg/kg reduces thrombus weight in a mouse model of venous thrombosis at 1 and 2 mg/kg
Cayman Chemical Ser159-PKCε149-164trIf 25mg
A chalcone with diverse biological activities activates Nrf2 and Hsf1 (EC50s 14.1 and 7.9 UM respectively in reporter assays) increases GSH levels and protects against hydrogen peroxide-induced cytotoxicity in HepG2 cells inhibits LPS-induced increases in iNOS COX-2 NO and PGE2 levels in RAW 264.7 macrophages at 10 and 20 UM induces apoptosis in T24 bladder cancer cells at 12.5 Ug/ml reduces tumor growth in an EJ bladder cancer mouse xenograft model at 50 mg/kg
Cayman Chemical SotaglIflozIn 25mg
A number of 17-phenyl trinor PGF2a derivatives have been approved for the treatment of glaucoma 894193418839 Of these the ones wherein the 1314-double bond has been hydrogenated retain relatively good potency but show a significantly reduced incidence of local irritant side effects 9736 17-trifluoromethylphenyl-1314-dihydro trinor PGF2a bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost (( )-fluprostenol isopropyl ester) As an ocular hypotensive agent it would be expected that 17-trifluoromethylphenyl-1314-dihydro trinor PGF2a would act very much like the free acid of latanoprost
Cayman Chemical DermorphInacetate 25mg
A coumarin with diverse biological activities scavenges DPPH radicals ABTS radicals and hydrogen peroxide in cell-free assays (IC50s 44 1 37 4 and 40 5 M respectively) selectively reduces cell viability in a panel of six NSCLC cell lines (IC50s 20 12-61 36 M) over noncancerous cell lines (IC50s 100 M) reduces levels of AST ALT and TBIL in serum decreases hepatic expression of TNF-a IL-6 IL-1B and COX-2 and attenuates hepatic fibrosis in a rat model of carbon tetrachloride-induced liver fibrosis at 25 and 50 mg/kg
Cayman Chemical VIncrIstInsulfate 25mg
CYPMPO is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems 14615 Decay of the superoxide adduct of CYPMPO proceeds in an apparent first order fashion with half-lives of 15 and 51 minutes in a UV-illuminated hydrogen peroxide solution and a hypoxanthine/xanthine oxidase system respectively CYPMPO traps superoxide radicals generated by bovine neutrophils as effectively as DEPMPO 14615 The high melting point (126 C) low hygroscopic properties and long shelf-life in aqueous solutions offer significant practical advantages for use of CYPMPO over DEPMPO and DMPO
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