General Clinical Chemistry Analyzers and Accessories
General Clinical Chemistry Analyzers and Accessories
AdipoGen Antipain dihydrochloride
Chemical. CAS 37682-72-7. Formula C27H44N10O6 . 2HCl. MW 604.7 . 72.9. Synthetic. Potent reversible inhibitor of serine/cysteine proteases and some trypsin-like proteases. Inhibits papain, trypsin and trypsin-like serine proteases as well as cathepsin A, B and D. Similar activity spectrum comparable to leupeptin AG-CP3-7000. Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase. Inhibits transformation of NIH3T3 cells after transfection with an activated H-ras oncogene. Used to evaluate the role of proteases in the process of malignant cell transformations. Shows antibacterial and antiparasitic activity.
AdipoGen Antipain dihydrochloride
Chemical. CAS 37682-72-7. Formula C27H44N10O6 . 2HCl. MW 604.7 . 72.9. Synthetic. Potent reversible inhibitor of serine/cysteine proteases and some trypsin-like proteases. Inhibits papain, trypsin and trypsin-like serine proteases as well as cathepsin A, B and D. Similar activity spectrum comparable to leupeptin AG-CP3-7000. Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase. Inhibits transformation of NIH3T3 cells after transfection with an activated H-ras oncogene. Used to evaluate the role of proteases in the process of malignant cell transformations. Shows antibacterial and antiparasitic activity.
AdipoGen S-Adenosylmethionine
Chemical. CAS 29908-03-0. Formula C15H22N6O5S. MW 398.44. S-Adenosylmethionine SAM is the first product of the methionine cycle and is implicated in the synthesis of polyamines and in the transsulfuration pathway leading to homocysteine and reduced glutathione GSH biosynthesis. SAM is synthesized from methionine and ATP in a reaction catalyzed by methionine adenosyltransferases MATs. These enzymes are encoded by two genes, MAT1A and MAT2A. SAM plays an essential role as methyl-donor for the methylation reactions during which it is transformed to S-adenosylhomocysteine SAH. SAH, a strong inhibitor of transmethylations, is transformed to homocysteine HCY by a specific hydroxylase. The methionine cycle plays a fundamental role in the cellular metabolism and the alteration of its functionality causes important disorders linked to modification of DNA methylation and gene expression, redox imbalance and metabolic reprogramming in liver and brain.
AdipoGen S-Adenosylmethionine
Chemical. CAS 29908-03-0. Formula C15H22N6O5S. MW 398.44. S-Adenosylmethionine SAM is the first product of the methionine cycle and is implicated in the synthesis of polyamines and in the transsulfuration pathway leading to homocysteine and reduced glutathione GSH biosynthesis. SAM is synthesized from methionine and ATP in a reaction catalyzed by methionine adenosyltransferases MATs. These enzymes are encoded by two genes, MAT1A and MAT2A. SAM plays an essential role as methyl-donor for the methylation reactions during which it is transformed to S-adenosylhomocysteine SAH. SAH, a strong inhibitor of transmethylations, is transformed to homocysteine HCY by a specific hydroxylase. The methionine cycle plays a fundamental role in the cellular metabolism and the alteration of its functionality causes important disorders linked to modification of DNA methylation and gene expression, redox imbalance and metabolic reprogramming in liver and brain.
AdipoGen Epoxidized soya bean oil
Chemical. CAS 8013-07-8. Synthetic. Useful for the determination of ESBO in foods with HPLC-MS or GC-MS. ESBO is currently employed as plasticizer and HCl scavenger in PVC products. Vegetable oils are widely used for chemical manipulation because of the high numbers of carbon-carbon double bonds. Through the epoxidation, an epoxide group which is a more reactive group than a double bond is added to the soybean oil, transforming it in a good hydrochloric acid scavenger and good plasticizer.
AdipoGen Epoxidized linseed oil
Chemical. CAS 8016-11-3. Synthetic. Useful for the determination of ELO in foods with HPLC-MS or GC-MS. ELO is currently employed as plasticizer and HCl scavenger in PVC products. Vegetable oils are widely used for chemical manipulation because of the high numbers of carbon-carbon double bonds. Through the epoxidation, an epoxide group which is a more reactive group than a double bond is added to the soybean oil, transforming it in a good hydrochloric acid scavenger and good plasticizer. It is also used as a reactive chemical intermediate due to its high oxirane content.
AdipoGen Epoxidized linseed oil
Chemical. CAS 8016-11-3. Synthetic. Useful for the determination of ELO in foods with HPLC-MS or GC-MS. ELO is currently employed as plasticizer and HCl scavenger in PVC products. Vegetable oils are widely used for chemical manipulation because of the high numbers of carbon-carbon double bonds. Through the epoxidation, an epoxide group which is a more reactive group than a double bond is added to the soybean oil, transforming it in a good hydrochloric acid scavenger and good plasticizer. It is also used as a reactive chemical intermediate due to its high oxirane content.