Drug Discovery Research Screening Libraries
Drug Discovery Research Screening Libraries
Enzo Life Sciences SCREEN-WELL Purinergic ligand library (100µl/well)
The SCREEN-WELL Purinergic and Adenosine Ligands Plate contains 72 CNS receptor ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Purinergic and Adenosine Ligands Plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 650 ligands. Long Term Storage: -80°C. Applications: HTS .
Enzo Life Sciences SCREEN-WELL Purinergic ligand library (500 µl/well)
The SCREEN-WELL Purinergic and Adenosine Ligands Plate contains 72 CNS receptor ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Purinergic and Adenosine Ligands Plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 650 ligands. Long Term Storage: -80°C. Applications: HTS .
AdipoGen Paeoniflorin
Chemical. CAS 23180-57-6. Formula C23H28O11. MW 480.46. Paeoniflorin has diverse cellular actions, including modulating NMDA and TRPV1 receptors. It is reported to inhibit testosterone synthesis and stimulate aromatase activity. It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-2/9 and ERK signaling. It has been described as an adenosine A1 receptor activator with neuroprotective and antidepressant effects, as well as hypoglycemic activity. It can activate adenosine A-1 receptors to increase the translocations of PKC and GLUT4, two major signals for glucose uptake, from cytosol to membrane of the white adipocytes in rats. Recently it also was described as a liver X receptor LXR agonist, that can act as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects.
AdipoGen Paeoniflorin
Chemical. CAS 23180-57-6. Formula C23H28O11. MW 480.46. Paeoniflorin has diverse cellular actions, including modulating NMDA and TRPV1 receptors. It is reported to inhibit testosterone synthesis and stimulate aromatase activity. It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-2/9 and ERK signaling. It has been described as an adenosine A1 receptor activator with neuroprotective and antidepressant effects, as well as hypoglycemic activity. It can activate adenosine A-1 receptors to increase the translocations of PKC and GLUT4, two major signals for glucose uptake, from cytosol to membrane of the white adipocytes in rats. Recently it also was described as a liver X receptor LXR agonist, that can act as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects.
AdipoGen Paeoniflorin
Chemical. CAS 23180-57-6. Formula C23H28O11. MW 480.46. Paeoniflorin has diverse cellular actions, including modulating NMDA and TRPV1 receptors. It is reported to inhibit testosterone synthesis and stimulate aromatase activity. It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-2/9 and ERK signaling. It has been described as an adenosine A1 receptor activator with neuroprotective and antidepressant effects, as well as hypoglycemic activity. It can activate adenosine A-1 receptors to increase the translocations of PKC and GLUT4, two major signals for glucose uptake, from cytosol to membrane of the white adipocytes in rats. Recently it also was described as a liver X receptor LXR agonist, that can act as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects.
AdipoGen Adenine
Chemical. CAS 73-24-5. Formula C5H5N5. MW 135.13. Adenine is a purine nucleobase. It is part of DNA and RNA and is also a component of cofactors NAD, FAD and signaling molecules cAMP. Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease CKD with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds. Adenine is suitable for use as a media nucleic acid base supplement in cell culture or food/dietary research.
AdipoGen Adenine
Chemical. CAS 73-24-5. Formula C5H5N5. MW 135.13. Adenine is a purine nucleobase. It is part of DNA and RNA and is also a component of cofactors NAD, FAD and signaling molecules cAMP. Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease CKD with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds. Adenine is suitable for use as a media nucleic acid base supplement in cell culture or food/dietary research.
AdipoGen Dimethyl fumarate
Chemical. CAS 624-49-7. Formula C6H8O4. MW 144.1. Immunomodulatory and anti-inflammatory agent used in patients with relapsing-remitting multiple sclerosis MS and psoriasis. Causes an immune switch characterized by induction of anti-inflammatory/regulatory innate and adaptive immune cell populations such as regulatory T cells Tregs and inhibition or apoptosis of pro-inflammatory cells, such as T helper 1 Th1 and Th17 subsets. Blocks immune cell activation through inhibition of glycolysis via post-transcriptional modification succination of glyceraldehyde 3-phosphate dehydrogenase GAPDH in vitro and in vivo and is therefore a useful agent for immunometabolism research. GAPDH catalyzes the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate during glycolysis, an essential metabolic pathway where glucose is converted to pyruvate, to fuel the TCA cycle and oxidative phosphorylation OXPHOS for the production of adenosine triphosphate ATP as an energy source.
AdipoGen Dimethyl fumarate
Chemical. CAS 624-49-7. Formula C6H8O4. MW 144.1. Immunomodulatory and anti-inflammatory agent used in patients with relapsing-remitting multiple sclerosis MS and psoriasis. Causes an immune switch characterized by induction of anti-inflammatory/regulatory innate and adaptive immune cell populations such as regulatory T cells Tregs and inhibition or apoptosis of pro-inflammatory cells, such as T helper 1 Th1 and Th17 subsets. Blocks immune cell activation through inhibition of glycolysis via post-transcriptional modification succination of glyceraldehyde 3-phosphate dehydrogenase GAPDH in vitro and in vivo and is therefore a useful agent for immunometabolism research. GAPDH catalyzes the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate during glycolysis, an essential metabolic pathway where glucose is converted to pyruvate, to fuel the TCA cycle and oxidative phosphorylation OXPHOS for the production of adenosine triphosphate ATP as an energy source.
AdipoGen AdipoRon HCl water soluble
Chemical. CAS 924416-43-3 free base. Formula C27H28N2O3 . HCl . H2O. MW 428.5 . 36.5 . 18.0. Orally-active adiponectin receptor AdipoR agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5-adenosine monophosphate-activated protein kinase AMPK in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha PGC1alpha which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice AdipoRs KO on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.