Cayman Chemical AdenosIn A2A Receptrhumn 10ug
A histamine H1 receptor antagonist (Ki 38.4 nM in cell membranes expressing human recombinant H1 receptors) reduces histamine-induced IL-6 and IL-8 production in human conjunctival epithelial cells (IC50s 1 and 0.652 M respectively) prevents anaphylaxis in rabbits sensitized to egg albumin and increases survival in a guinea pig model of histamine-induced bronchospasm eliminates atrial fibrillation induced by acetylcholine and isoproterenol in isolated rabbit hearts by increasing the atrial effective refractory period and interatrial conduction time in a dose-dependent manner binds to NMDA receptors (Ki 13 M) and reduces glutamate-induced toxicity in cerebellar granule cells (EC50 13 M)