Oxazinanes
Oxazinanes
TARGETMOL CHEMICALS INC Temiverine hydrochloride 1MG
Also available in 5 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Temiverine hydrochloride is a potential calcium channel antagonist with anticholinergic effects that inhibits some of the functions of atropine. Purity 99.43%
AdipoGen Caroverine hydrochloride
Chemical. CAS 55750-05-5. Formula C22H27N3O2 . HCl . H2O. MW 401.93 . 18.0. Synthetic. Nonselective NMDA and AMPA glutamate receptor antagonist. A class B calcium-channel-blocker, antiglutamatergic agent and shown to act as an antioxidant.
AdipoGen Caroverine hydrochloride
Chemical. CAS 55750-05-5. Formula C22H27N3O2 . HCl . H2O. MW 401.93 . 18.0. Synthetic. Nonselective NMDA and AMPA glutamate receptor antagonist. A class B calcium-channel-blocker, antiglutamatergic agent and shown to act as an antioxidant.
TARGETMOL CHEMICALS INC BENIDIPINE HYDROCHLORIDE 200MG
Also available in 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Benidipine hydrochloride (Coniel) a hydrochloride salt form of benidipine is used as a blocker of dihydropyridine calcium channel. purity: 99%
TARGETMOL CHEMICALS INC Tiapamil hydrochloride 1MG
Also available in 2 mg, 5 mg, 10 mg, 25 mg, 50 mg and bulk. Please contact Fisher for quotes. Tiapamil hydrochloride (Ro 11-1781 hydrochloride) is a calcium channel blocker with antihypertensive activity and may be used in the study of angina and cardiovascular disease. Purity 98.47%
TARGETMOL CHEMICALS INC GALLOPAMIL HYDROCHLORIDE 25MG
Also available in 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies. purity: 99%
TARGETMOL CHEMICALS INC NPS-2143 HYDROCHLORIDE 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist. purity: 99%
TARGETMOL CHEMICALS INC Etelcalcetide hydrochloride
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide that serves as an allosteric modulator of the calcium-sensing receptor (CaSR), effectively reducing parathyroid hormone (PTH) levels in patients with secondary hyperparathyroidism undergoing hemodialysis. Purity 100%
Cayman Chemical 3-MethylglutaconIc AcId 250mg
A peptide ETB receptor antagonist (IC50 1.2 nM) selective for ETB over ETA receptors (IC50 280 nM) as well as angiotensin calcitonin or neuropeptide receptors at 10 UM inhibits ET-1-induced calcium mobilization in human Girrardi heart cells (IC50 0.54 nM) and BQ-3020-induced vasoconstriction in isolated rat pulmonary arteries (pA2 8.4) inhibits ET-1 induced depressor responses and induces pressor responses in rats at 1 mg/kg protects against laparotomy and surgical gut handling-induced inhibition of intestinal motility in rats attenuates delayed hypotension vascular hyporeactivity to norepinephrine and hepatocellular injury and dysfunction in a rat model of LPS-induced endotoxemia
AdipoGen Verapamil hydrochloride
Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.
AdipoGen Verapamil hydrochloride
Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.
AdipoGen Verapamil hydrochloride
Chemical. CAS 152-11-4. Formula C27H38N2O4 . HCl. MW 491.06. Synthetic Verapamil hydrochloride is an alpha-adrenergic receptor alpha-AR antagonist and calcium channel protein inhibitor that blocks the L-type Ca2 channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr P-glycoprotein. Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models.
TARGETMOL CHEMICALS INC SKF-96365 HYDROCHLORIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SKF-96365 hydrochloride (SKF96365) a SOCE inhibitor exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically SKF-96365 hydrochloride treatment inhibited the calcium/calmodulin-dependent protein kinase II(gamma) (CaMKII(gamma))/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKII(gamma) or AKT abolished the effects of SKF-96365 on Y cells suggesting a critical role of the CaMKII(gamma)/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner. purity: 99%