Pyrazines
Pyrazines
TARGETMOL CHEMICALS INC ELAMIPRETIDE 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 200 mg and bulk. Please contact Fisher for quotes. Elamipretide (SS-31MTP-131Bendavia) is a small mitochondrially-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that appears to reduce the production of toxic reactive oxygen species and stabilize cardiolipin. purity: 99%
AdipoGen 2 7-Dichlorofluorescein
Chemical. CAS 76-54-0. Formula C20H10Cl2O5. MW 401.2. Synthetic Fluorescent dye. Spectral data Extinction 504nm/Emmission 529nm, in 0.1 M Tris pH 8.0. Used for the determination of carbohydrates by fluorescence densitometry after TLC, in the determination of H2O2 by chemiluminescence, and as a fluorescent additive used in indirect fluorimetric detection in OTC-HPLC. Used as a component/substrate of the 2,7-dichlorofluorescein diacetate DCFH-DA assay to quantitate reactive oxygen species ROS.
AdipoGen 2 7-Dichlorofluorescein
Chemical. CAS 76-54-0. Formula C20H10Cl2O5. MW 401.2. Synthetic Fluorescent dye. Spectral data Extinction 504nm/Emmission 529nm, in 0.1 M Tris pH 8.0. Used for the determination of carbohydrates by fluorescence densitometry after TLC, in the determination of H2O2 by chemiluminescence, and as a fluorescent additive used in indirect fluorimetric detection in OTC-HPLC. Used as a component/substrate of the 2,7-dichlorofluorescein diacetate DCFH-DA assay to quantitate reactive oxygen species ROS.
TARGETMOL CHEMICALS INC HIF-2ALPHA AGONIST 2 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. HIF-2(alpha) agonist 2 is an HIF-2(alpha) agonist with an EC50 value of 1.68 uM for HIF-2(alpha). HIF-2(alpha) agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reha-Luc cells. HIF-2(alpha) agonist 2 can be used in the study of oxygen metabolism and is closely related to the occurrence of cancer. purity: 98%
TARGETMOL CHEMICALS INC NEOBAVAISOFLAVONE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity can significantly inhibit the production of reactive oxygen species (ROS) reactive nitrogen species (RNS) and cytokines IL-1(beta) IL-6 IL-12p4 IL-12p7 TNF-(alpha) in LPS+IFN-(gamma)- or PMA- stimulated RAW264.7 macrophages. purity: 99%
TARGETMOL CHEMICALS INC CIL56 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated monounsaturated and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1) the rate-limiting enzyme in fatty acid synthesis exhibit 5-fold resistance to CIL56 treatment indicating ACC1 activity sensitizes cells to CIL56-induced cell death. purity: 99%
TARGETMOL CHEMICALS INC MMRI62 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MMRi62 (7-[(23-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol) a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53 also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12. purity: 99%
TARGETMOL CHEMICALS INC NEFERINE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Neferine ((-)-Neferine) has anti-tumor activities Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-(kappa)B pathway which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species activation of MAPKs lipid peroxidation depletion of cellular antioxidant pool loss of mitochondrial membrane potential and intracellular calcium accumulation. purity: 99%