Antibodies are glycoproteins that serve an essential role in the immune system to protects animals from infection, or the cytotoxic effects of foreign compounds, by binding with high affinity to invasive molecules; classified as primary or secondary.
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Interleukin 5 (IL-5) is a secreted protein produced by Th2-polarized T cells and mast cells. IL-5 stimulates cell division, increased antibody production, and isotype-switching in B cells.
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CD140a, also known as platelet-derived growth factor receptor-? (PDGFR-?), is one of two receptors for platelet-derived growth factors (PDGFs), and is associated with various malignancies.
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CD48, also known as BCM-1, is a member of the signaling lymphocyte activation molecule (SLAM) family of proteins. It is expressed on T cells, B cells, and monocytes/macrophages.
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CD1d, also known as CD1.1 and Ly-38, is a 48 kDa type I membrane glycoprotein with structural homology to harmful MHC class I molecules. It is noncovalently associated with ?2-microglobulin.
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CD86, also known as B7-2, B70, and Ly-58, is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4).
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CD357, also known as GITR (glucocorticoid-induced TNFR family gene), and its ligand (GITRL) are induced upon activation of a number of immune cell types.
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CD122 (IL-2R?) is a 70–75 kDa member of the immunoglobulin superfamily that, along with CD25 (IL-2R?) and CD132 (common ? chain), forms the receptor for the IL-2 cytokine.
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CD4, also known as T4, is a transmembrane glycoprotein expressed on the helper subset of T cells (thymocytes), on immature T cells in the thymus, and weakly on monocytes and dendritic cells. CD4 helps recognize antigens associated with MHC class II molecules via initiation of signal transduction and controlling of cell-cell interaction.
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CD19, also known as B4, is a type I transmembrane glycoprotein that is a member of the immunoglobulin superfamily. CD19 is expressed on B cells, B cell progenitors, and follicular dendritic cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI 3-kinase.
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CD28 is a 45 kDa disulfide-linked homodimeric type I glycoprotein. CD28 binds to CD80 and CD86 and can be expressed on T cells, NK cell subsets, and plasma cells. Expression of CD28 on T cells provides co-stimulatory signals, which is required for T cell activation for the production of various interleukins (IL-2 and IL-6 in particular).
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