Primary antibodies are immunoglobulins that recognize and bind to a specific antigen of interest with high affinity and specificity to purify, detect, and measure that antigen. Includes antibody pairs for specific biochemical applications.
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Interleukin 5 (IL-5) is a secreted protein produced by Th2-polarized T cells and mast cells. IL-5 stimulates cell division, increased antibody production, and isotype-switching in B cells.
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CD140a, also known as platelet-derived growth factor receptor-? (PDGFR-?), is one of two receptors for platelet-derived growth factors (PDGFs), and is associated with various malignancies.
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CD48, also known as BCM-1, is a member of the signaling lymphocyte activation molecule (SLAM) family of proteins. It is expressed on T cells, B cells, and monocytes/macrophages.
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CD1d, also known as CD1.1 and Ly-38, is a 48 kDa type I membrane glycoprotein with structural homology to harmful MHC class I molecules. It is noncovalently associated with ?2-microglobulin.
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CD86, also known as B7-2, B70, and Ly-58, is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4).
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CD357, also known as GITR (glucocorticoid-induced TNFR family gene), and its ligand (GITRL) are induced upon activation of a number of immune cell types.
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CD122 (IL-2R?) is a 70–75 kDa member of the immunoglobulin superfamily that, along with CD25 (IL-2R?) and CD132 (common ? chain), forms the receptor for the IL-2 cytokine.
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CD4, also known as T4, is a transmembrane glycoprotein expressed on the helper subset of T cells (thymocytes), on immature T cells in the thymus, and weakly on monocytes and dendritic cells. CD4 helps recognize antigens associated with MHC class II molecules via initiation of signal transduction and controlling of cell-cell interaction.
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CD19, also known as B4, is a type I transmembrane glycoprotein that is a member of the immunoglobulin superfamily. CD19 is expressed on B cells, B cell progenitors, and follicular dendritic cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI 3-kinase.
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CD28 is a 45 kDa disulfide-linked homodimeric type I glycoprotein. CD28 binds to CD80 and CD86 and can be expressed on T cells, NK cell subsets, and plasma cells. Expression of CD28 on T cells provides co-stimulatory signals, which is required for T cell activation for the production of various interleukins (IL-2 and IL-6 in particular).
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