Custom Products and Services
Custom Products and Services
Tocris Bioscience™ Adenosine
Endogenous adenosine receptor agonist
Tocris Bioscience™ (±)-5'-Chloro-5'-deoxy-ENBA
Highly selective A1 agonist
Tocris Bioscience™ ABT 702 hydrochloride
Adenosine kinase inhibitor; orally active
Tocris Bioscience™ Cladribine
Deoxyadenosine analog; pro-apoptotic
Tocris Bioscience™ Toyocamycin
Adenosine analog; antifungal antibiotic
Revvity Health Sciences Inc Adenosine A1R fluorescent probe, 1 Unit
Tag-lite receptor binding assays use either a green or a red fluorescent ligand to function. This Adenosine A1 receptor red antagonist is a XAC derivative labeled with a red emitting HTRF fluorescent probe. This ligand is best suited for use in the Adenosine A1 receptorbinding assay.
Revvity Health Sciences Inc Adenosine A3R fluorescent probe, 1 Unit
Tag-lite receptor binding assays use either a green or a red fluorescent ligand to function. This Adenosine A3 receptor green antagonist is a XAC derivative labeled with a green emitting HTRF fluorescent probe. This ligand is best suited for use in the Adenosine A3 receptorbinding assay.
Enzo Life Sciences SCREEN-WELL Purinergic ligand library (100µl/well)
The SCREEN-WELL Purinergic and Adenosine Ligands Plate contains 72 CNS receptor ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Purinergic and Adenosine Ligands Plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 650 ligands. Long Term Storage: -80°C. Applications: HTS .
Enzo Life Sciences SCREEN-WELL Purinergic ligand library (500 µl/well)
The SCREEN-WELL Purinergic and Adenosine Ligands Plate contains 72 CNS receptor ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Purinergic and Adenosine Ligands Plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 650 ligands. Long Term Storage: -80°C. Applications: HTS .
Cayman Chemical MLN4924, 905579-51-3, 1 mg
Molecular Formula C21H25N5O4S, Purity ≥98%, Formula Weight 443.5, Synonyms: Pevonedistat; An analog of adenosine 5'-monophosphate that selectively inhibits NAE (IC50 = 4.7 nM) and disrupts CRL-mediated protein turnover leading to apoptosis in cancer cells by deregulating S-phase DNA synthesis.
AdipoGen Paeoniflorin
Chemical. CAS 23180-57-6. Formula C23H28O11. MW 480.46. Paeoniflorin has diverse cellular actions, including modulating NMDA and TRPV1 receptors. It is reported to inhibit testosterone synthesis and stimulate aromatase activity. It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-2/9 and ERK signaling. It has been described as an adenosine A1 receptor activator with neuroprotective and antidepressant effects, as well as hypoglycemic activity. It can activate adenosine A-1 receptors to increase the translocations of PKC and GLUT4, two major signals for glucose uptake, from cytosol to membrane of the white adipocytes in rats. Recently it also was described as a liver X receptor LXR agonist, that can act as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects.
AdipoGen Paeoniflorin
Chemical. CAS 23180-57-6. Formula C23H28O11. MW 480.46. Paeoniflorin has diverse cellular actions, including modulating NMDA and TRPV1 receptors. It is reported to inhibit testosterone synthesis and stimulate aromatase activity. It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-2/9 and ERK signaling. It has been described as an adenosine A1 receptor activator with neuroprotective and antidepressant effects, as well as hypoglycemic activity. It can activate adenosine A-1 receptors to increase the translocations of PKC and GLUT4, two major signals for glucose uptake, from cytosol to membrane of the white adipocytes in rats. Recently it also was described as a liver X receptor LXR agonist, that can act as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects.
AdipoGen Paeoniflorin
Chemical. CAS 23180-57-6. Formula C23H28O11. MW 480.46. Paeoniflorin has diverse cellular actions, including modulating NMDA and TRPV1 receptors. It is reported to inhibit testosterone synthesis and stimulate aromatase activity. It also reduces inflammatory signaling by inhibiting p38 MAP kinase and blocks pancreatic cancer cell apoptosis by suppressing MMP-2/9 and ERK signaling. It has been described as an adenosine A1 receptor activator with neuroprotective and antidepressant effects, as well as hypoglycemic activity. It can activate adenosine A-1 receptors to increase the translocations of PKC and GLUT4, two major signals for glucose uptake, from cytosol to membrane of the white adipocytes in rats. Recently it also was described as a liver X receptor LXR agonist, that can act as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects.
AdipoGen Adenine
Chemical. CAS 73-24-5. Formula C5H5N5. MW 135.13. Adenine is a purine nucleobase. It is part of DNA and RNA and is also a component of cofactors NAD, FAD and signaling molecules cAMP. Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease CKD with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds. Adenine is suitable for use as a media nucleic acid base supplement in cell culture or food/dietary research.
AdipoGen Adenine
Chemical. CAS 73-24-5. Formula C5H5N5. MW 135.13. Adenine is a purine nucleobase. It is part of DNA and RNA and is also a component of cofactors NAD, FAD and signaling molecules cAMP. Adenine is essential for many in vivo and in vitro biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease CKD with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds. Adenine is suitable for use as a media nucleic acid base supplement in cell culture or food/dietary research.
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