Bioactive Small Molecules
Bioactive Small Molecules
Tocris Bioscience™ Blasticidin S HCl
Antibiotic; selection reagent for bis, bsr and BSD transformed cells
Tocris™ SM 16
Potent TGF-β receptor type 1 (TGF-βRI) inhibitor
Tocris Bioscience™ N-Acetylpuromycin
Downregulates SnoN and Ski protein expression; promotes TGF-β signaling
Tocris Bioscience™ AZ 12799734
Potent TGF-βRI inhibitor
Tocris Bioscience™ A 83-01
A 83-01 synthesized to Ancillary Material Grade
Tocris Bioscience™ LY 2109761
Selective TGF-β kinase inhibitor
Tocris Bioscience™ RepSox
RepSox synthesized to Ancillary Material Grade
SB 431542, Tocris Bioscience™
Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
Cayman Chemical DRIbulose5phosphATsodIu 5mg
A bicyclic guanidine base that can be used as a catalyst for a variety of base-mediated organic transformations
Cayman Chemical PB22 N 5hydroxypentyl3c 5mg
Bicyclo Prostaglandin E1 (bicyclo PGE1) is a stable base-catalyzed transformation product of the PGE1 metabolite 1314-dihydro-15-keto PGE1. Bicyclo PGE1 is a stable base-catalyzed transformation product of the PGE1 metabolite 1314-dihydro-15-keto PGE1. 1314-dihydro-15-keto PGE1 itself is a metabolite of PGE1{1822126} found in human plasma at a median level of 10 pg/ml.{4383} Due to the inherent instability of 1314-dihydro-15-keto PGE1 it is advisable to quantify it as bicyclo PGE1 to estimate PGE1 biosynthesis or metabolism in vivo.
Cayman Chemical Asunaprevr 5mg
A cell-permeable analog of FPP that potently inhibits FTase (IC50 50-75 nM) preventing farnesylation of Ras does not inhibit geranylgeranyl transferase at similar concentrations (IC50 100 UM) blocks Ras-mediated transformation of NIH 3T3 cells
Active Motif Trichostatin A
Active Motif's Trichostatin A is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). It induces reversion of ras-transformed cells to normal morphology and induces dedifferentiation of primordial germ cells into embryonic germ cells. It is cell permeable, and is active in vivo.
Selleck Chemical LLC GNF-2 5mg 778270-11-4
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl, shows no activity to Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical AtractylosIdepotasIum salt 5mg
A DOT1L inhibitor (IC50 0.3 nM) selective for DOT1L over a panel of 12 additional protein methyltransferases DNMT1 and a panel of 29 receptors and ion channels reduces H3K79me2 levels in MCF-10A breast cancer cells (IC50 8.8 nM) selectively reduces the viability of isolated human cord blood cells transformed with an MLL-AF9 fusion oncogene over those transformed with a TLS-ERG fusion oncogene at 1 and 5 UM adoptive transfer of isolated human CD3 T cells pre-incubated with SGC0946 (0.5 UM) prevents weight loss increases survival and reduces hepatic and colonic lymphocyte infiltration in a xenogeneic mouse model GVHD
Cayman Chemical C6 PhytoceramIdet18 06 0 5mg
A phenol secreted by wounded plant tissues induces expression of virulence A genes and chemotaxis in A. tumefaciens strains that contain a tumor-inducing plasmid used to transfer genetic information to plant cells widely used to increase efficacy of genetic transformation for the creation of genetically modified dicotyledonous and monocotyledonous plants